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Soline
Aubry
saubry@ens-lyon.fr
May
- August 2002
Visiting
Scholar from the École Normale Supérior
de Lyon, France.
November
2000 - present: Ph.D student
Magistère
des Sciences de la Matière
Feb.
2002 - present: bioinorganic chemistry
The
enzyme Hydroxylamine Oxidoreductase (HAO) catalyzes
the oxidative conversion of hydroxylamine to nitrite
in the nitrogen cycle. The functional unit in vivo is
a peptide trimer, which consists of 24(!) heams. HAO
represents one the most complex and unusual structures
in biochemistry. We will design water-soluble, tetraaza-amine
and -imine macrocyclic ligands to synthesize inorganic
analogues of the active site P-460 and explore the complexes
reactivity towards biologically relevant substrates
such as NH2OH, N2H4, N2O, and NO. Di-iron complexes
of binucleating ligands will allow us to investigate
the importance of metal-metal interactions in catalysis.
The ultimate goal of this research is to broaden our
understanding of the interplay of the active site, covalently
bound and potentially redox-active side-chains, and
electron acceptors during the course of the hydroxylamine
oxidation.
June
- July 2001
Department
of Chemistry, Imperial College, London
Project:
Asymmetric Epoxidation of Amines with Prof. Alan Armstrong
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